Pigment Serum Model


Contains 4% Hydroquinone which lightens discolorations in the skin such as freckles, age spots or pigment. Dramatically improves skin color by inhibiting the production of excessive skin pigment that can lead to uneven color or dark spots. FADE-4 slows the production of melanin in skin cells that are over producing this substance. By regulating the production of pigment, use of FADE-4 leads to more even color.

FADE-4 cream can be used twice a day to achieve optimal results rapidly. At morning, wash your face with a cleanser. Apply a thin coat of FADE-4 over the treated area. After 30 minutes, apply an SPF of 15 or greater. Apply cosmetics normally. At night, wash your face. Apply a thin coat of FADE-4 over area to be treated. When using multiple skin care products, always follow your dermatologist instructions. If using products such as tretinoin (Retin-A) or alpha hydroxy acid, apply these products first and wait 30 minutes before applying FADE-4. The less product you use, the less chance of irritation there is. Many bleaching products are aggressive and it can be hard to combine bleaching products with other products without irritation. If you should experience any type of irritation, redness or a rash while you are using FADE-4, discontinue using it and contact your dermatologist. After a few months of twice a day usage, you may use FADE-4 once a day for maintenance therapy. You may consider wearing protective clothing to help reduce the amount of sun exposure (i.e. long sleeves, broad rimmed hat). Keep FADE-4 out of the reach of children. In case of accidental ingestion, call a physician or poison control center immediately.

You may see a decrease in pigmentation and an overall improvement in skin tone and clarity within six to eight weeks. When using FADE-4 on the hands or chest, visible results may take a little longer because the skin on those areas of the body tends to be more difficult to penetrate. FADE-4 may changes color from white to almond with exposure to air. This does not change how well FADE-4 works.

Water, Glyceryl Stearate, PEG-100 Stearate, Propylene Glycol. Hydroquinone, Cetearyl Alcohol, Cetyl Palmitate, Ceteareth-12, Isopropyl Palmitate, Benzophenone-3, Phenoxyethanol, Sodium Sulfite, Dimethicone, Octyl Methoxycinnamate, Ascorbic Acid, Methylparaben, Propylparaben, Disodium EDTA, Fragrance.

Hydroquinone is the most popular, and is also the most effective topical hypopigmenting agent. Hydroquinone works by inhibiting the conversion of tyrosine to melanin, inhibiting the formation of melanosomes and increase the degradation to melanosomes, and by inhibiting by inhibiting the DNA and RNA synthesis of melanocytes. As a result, hydroquinone affects only cells with active tyrosinase activity. Active tyrosine's activity is only found in epidermal melanocytes. In dermal melanin, tyrosinase activity is not present; therefore dermal melasma is resistant to hydroquinone. The efficacy of hydroquinone is related to the concentration of the preparation. Preparations with a hydroquinone concentration of 2% or less are less effective. Concentrations of 4% hydroquinone are very effective, but can be irritating. The chemical stability of hydroquinone formulations is important because hydroquinone is easily oxidized and loses potency. Hydroquinone formulation should be kept in no larger than 2 ounce and should be used within 90 days after opening. The lightening effect of hydroquinone can be enhanced by combining it with other agents such as alphahydroxy acids.

Lentigines (known as age spots) and ephelides (known as freckles) are tan, brown or black spots that appear over time on sun exposed areas of the skin. These spots are common on the backs of the hand, face and legs. Those who tan extensively will also have them over the shoulders, back, chest and other areas of the skin. Lentigines are superficial collections of skin pigment called melanin that have accumulated within the top layer of skin called the epidermis. Ephelides are common in lighter skin who sunburn easily. Lentigines usually appear later in life and may occur in all skin types. Lentigines are caused by prolonged sun exposure or sunburns and appear later in adult life. Ephelides occur even in children after brief periods of sun exposure. Both types of pigmented only rarely occur in non-sun exposed areas. Sun avoidance and the use of good sunscreen protection can help minimize the appearance of both lentigines and ephelides.

Melasma is commonly acquired increase of pigmentation that occurs in sun-exposed areas. Brown in color, it is severed by sun exposure, pregnancy, oral contraceptives, and certain anti-epilepsy drugs. Melasma is usually common, especially in women of childbearing age. However, up to 15% of cases have been reported in males. All races are affected, but there is a prominence among Asians and Latinos. Melasma is more apparent during and after periods of sun exposure and less obvious in winter months, when there is less sun. Melasma presents itself in one of the three usually symmetrical facial patterns. The most common is a Centrofacial pattern, the cheeks, forehead, upper lip, nose, and chin. Less common are the malar pattern, the cheeks and nose, and the mandibuylar pattern, the side of the cheeks and jaw line.

Freckles are common amongst a lot of people. Some patients have a variety known as "sunburn freckles" or ephelides. These are larger and darker than standard freckles that are brown color. The edges are irregular, but the pigment is even throughout the lesion. Sun-induced freckles are associated with non-melanoma and melanoma skin cancers.

Melasma has been considered to originate from pregnancy, oral contraceptives, endocrine dysfunction, genetic factors, medications, nutritional deficiency, hepatic dysfunction, and other factors. More cases appear to be related to pregnancy and oral contraceptives. The infrequency of melasma in postmenopausal women on estrogen replacement recommends that estrogen alone is not the cause. In more recent experience, combination treatment using estrogen plus progestational agents is being used in postmenopausal women, and melasma is being observed in some of these older women who did not have melasma during their pregnancies. Sun exposure is appears to be a stimulating factor in the predisposed individuals.

Pigmented skin spots can be treated with freezing, acids, skin sanding, electric needle and any other methods that cause a superficial destruction of the skin. These methods usually leave white spots and scars. Lasers are much more precise and less damaging to the skin because light is used to selectively remove the pigment without damaging the normal surrounding skin. Bleaching solutions such as hydroquinone can be useful to people with fair skin, though hydroquinone can sometimes irritate the skin. This possibility or irritation with hydroquinone makes it unsuitable for people with darker skin tones. It is possible that the irritation associated with hydroquinone can over stimulate the higher concentration of melanocytes found in dark skin types. This can lead to hyperpigmentation (dark spotting). Bleaching solutions work by killing the melanin in hyperpigmentated areas. Over time, this will lead to a fading of spots. It will not affect the natural skin color of the skin.

FADE-4 bleaching cream is a safe and effective way to lightens skin and treat pigmentation. With 4% hydroquinone formulation, fade freckles, age spots and melasma (mask of pregnancy). FADE-4 is an effective cream for helping people with skin abnormalities causing pigmentation.

Relevant Products from REXSOL (rexsol.com)


2.0 oz., Contains 2% Hydroquinone, 8% Lactic Acid and 2% Citric Acid. To help lighten hyperpigmentation on skin. $28.00
2.0 oz., Contains 2% hydroquinone. Lightens discolorations in the skin such as freckles, age spots. $22.00
2.0 fl. oz., Contains 2% hydroquinone. Lightens discolorations in the skin such as freckles, age spots.$22.00


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