4% Hydroquinone which lightens discolorations in the skin such as freckles,
age spots or pigment. Dramatically improves skin color by inhibiting
the production of excessive skin pigment that can lead to uneven color
or dark spots. FADE-4 slows the production of melanin in skin cells
that are over producing this substance. By regulating the production
of pigment, use of FADE-4 leads to more even color.
TO USE FADE-4:
FADE-4 cream can be used twice a day to achieve optimal results rapidly.
At morning, wash your face with a cleanser. Apply a thin coat of FADE-4
over the treated area. After 30 minutes, apply an SPF of 15 or greater.
Apply cosmetics normally. At night, wash your face. Apply a thin coat
of FADE-4 over area to be treated. When using multiple skin care products,
always follow your dermatologist instructions. If using products such
as tretinoin (Retin-A) or alpha hydroxy acid, apply these products first
and wait 30 minutes before applying FADE-4. The less product you use,
the less chance of irritation there is. Many bleaching products are
aggressive and it can be hard to combine bleaching products with other
products without irritation. If you should experience any type of irritation,
redness or a rash while you are using FADE-4, discontinue using it and
contact your dermatologist. After a few months of twice a day usage,
you may use FADE-4 once a day for maintenance therapy. You may consider
wearing protective clothing to help reduce the amount of sun exposure
(i.e. long sleeves, broad rimmed hat). Keep FADE-4 out of the reach
of children. In case of accidental ingestion, call a physician or poison
control center immediately.
FAST WILL FADE-4 WORKS ?
You may see a decrease in pigmentation and an overall improvement in
skin tone and clarity within six to eight weeks. When using FADE-4 on
the hands or chest, visible results may take a little longer because
the skin on those areas of the body tends to be more difficult to penetrate.
FADE-4 may changes color from white to almond with exposure to air.
This does not change how well FADE-4 works.
Water, Glyceryl Stearate, PEG-100 Stearate, Propylene Glycol. Hydroquinone,
Cetearyl Alcohol, Cetyl Palmitate, Ceteareth-12, Isopropyl Palmitate,
Benzophenone-3, Phenoxyethanol, Sodium Sulfite, Dimethicone, Octyl Methoxycinnamate,
Ascorbic Acid, Methylparaben, Propylparaben, Disodium EDTA, Fragrance.
IS HYDROQUINONE ?
Hydroquinone is the most popular, and is also the most effective topical
hypopigmenting agent. Hydroquinone works by inhibiting the conversion
of tyrosine to melanin, inhibiting the formation of melanosomes and
increase the degradation to melanosomes, and by inhibiting by inhibiting
the DNA and RNA synthesis of melanocytes. As a result, hydroquinone
affects only cells with active tyrosinase activity. Active tyrosine's
activity is only found in epidermal melanocytes. In dermal melanin,
tyrosinase activity is not present; therefore dermal melasma is resistant
to hydroquinone. The efficacy of hydroquinone is related to the concentration
of the preparation. Preparations with a hydroquinone concentration of
2% or less are less effective. Concentrations of 4% hydroquinone are
very effective, but can be irritating. The chemical stability of hydroquinone
formulations is important because hydroquinone is easily oxidized and
loses potency. Hydroquinone formulation should be kept in no larger
than 2 ounce and should be used within 90 days after opening. The lightening
effect of hydroquinone can be enhanced by combining it with other agents
such as alphahydroxy acids.
ARE PIGMENTED SPOTS ?
Lentigines (known as age spots) and ephelides (known as freckles) are
tan, brown or black spots that appear over time on sun exposed areas
of the skin. These spots are common on the backs of the hand, face and
legs. Those who tan extensively will also have them over the shoulders,
back, chest and other areas of the skin. Lentigines are superficial
collections of skin pigment called melanin that have accumulated within
the top layer of skin called the epidermis. Ephelides are common in
lighter skin who sunburn easily. Lentigines usually appear later in
life and may occur in all skin types. Lentigines are caused by prolonged
sun exposure or sunburns and appear later in adult life. Ephelides occur
even in children after brief periods of sun exposure. Both types of
pigmented only rarely occur in non-sun exposed areas. Sun avoidance
and the use of good sunscreen protection can help minimize the appearance
of both lentigines and ephelides.
Melasma is commonly acquired increase of pigmentation that occurs in
sun-exposed areas. Brown in color, it is severed by sun exposure, pregnancy,
oral contraceptives, and certain anti-epilepsy drugs. Melasma is usually
common, especially in women of childbearing age. However, up to 15%
of cases have been reported in males. All races are affected, but there
is a prominence among Asians and Latinos. Melasma is more apparent during
and after periods of sun exposure and less obvious in winter months,
when there is less sun. Melasma presents itself in one of the three
usually symmetrical facial patterns. The most common is a Centrofacial
pattern, the cheeks, forehead, upper lip, nose, and chin. Less common
are the malar pattern, the cheeks and nose, and the mandibuylar pattern,
the side of the cheeks and jaw line.
IS FRECKLES ?
Freckles are common amongst a lot of people. Some patients have a variety
known as "sunburn freckles" or ephelides. These are larger
and darker than standard freckles that are brown color. The edges are
irregular, but the pigment is even throughout the lesion. Sun-induced
freckles are associated with non-melanoma and melanoma skin cancers.
ARE THE CAUSES OF MELASMA?
Melasma has been considered to originate from pregnancy, oral contraceptives,
endocrine dysfunction, genetic factors, medications, nutritional deficiency,
hepatic dysfunction, and other factors. More cases appear to be related
to pregnancy and oral contraceptives. The infrequency of melasma in
postmenopausal women on estrogen replacement recommends that estrogen
alone is not the cause. In more recent experience, combination treatment
using estrogen plus progestational agents is being used in postmenopausal
women, and melasma is being observed in some of these older women who
did not have melasma during their pregnancies. Sun exposure is appears
to be a stimulating factor in the predisposed individuals.
ARE PIGMINTED SKIN SPOTS TREATED?
Pigmented skin spots can be treated with freezing, acids, skin sanding,
electric needle and any other methods that cause a superficial destruction
of the skin. These methods usually leave white spots and scars. Lasers
are much more precise and less damaging to the skin because light is
used to selectively remove the pigment without damaging the normal surrounding
skin. Bleaching solutions such as hydroquinone can be useful to people
with fair skin, though hydroquinone can sometimes irritate the skin.
This possibility or irritation with hydroquinone makes it unsuitable
for people with darker skin tones. It is possible that the irritation
associated with hydroquinone can over stimulate the higher concentration
of melanocytes found in dark skin types. This can lead to hyperpigmentation
(dark spotting). Bleaching solutions work by killing the melanin in
hyperpigmentated areas. Over time, this will lead to a fading of spots.
It will not affect the natural skin color of the skin.
bleaching cream is a safe and effective way to lightens skin and treat
pigmentation. With 4% hydroquinone formulation, fade freckles, age spots
and melasma (mask of pregnancy). FADE-4 is an effective cream for helping
people with skin abnormalities causing pigmentation.
Copyright VEN ZEL 2002, all rights reserved.